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Super Blue Stuff OTC Pain Relief Cream with Emu oil - what does the OTC mean? OTC means over-the-counter drug. Super Blue Stuff OTC Pain Relief Cream with Emu Oil qualifies as an over the counter drug and is registered with the FDA (Food and Drug Administration of the United States Government). The active ingredient is menthol, which comes from the peppermint plant. Topically applied - at certain levels -it is an analgesic pain reliever. Menthol has a slightly cooling effect. However, Blue Spring is very exacting in the amount it uses, because too much can cause a sensation that feels like a burning effect. The menthol in Super Blue Stuff OTC Pain Relief Cream with Emu Oil is just right...